Rapid metagenomic diagnostics of a suspected outbreak of severe pneumonia in Northern Germany

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03/29/13 • Patient 1 (49-year old police officer, immunocompetent) is admitted to the emergency room of the University Medical Centre Hamburg-Eppendorf after having suffered for one week from symptoms of pneumonia. • Patient is diagnosed with ARDS and mechanically ventilated in intensive care unit. • CRP (238mg/l) and CK (402) levels elevated, PCT: 71 • Leukocytosis (mainly neutrophils) • Antibitotic treatment with meropenem and clarithromycin initiated. • 1st bronchioalveolar lavage (BAL) collected, diagnostic tests performed on BAL: o PCR tests negative for: FLU A/B, PIV 1-4, RSV, CoV, Adenovirus, Bocavirus, Mycoplasma pneumonia, Chlamydophila pneumonia, Legionella o Cultivation negative after 48h o PCP negative

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تاریخ انتشار 2014